Members of this family of bacterial domains are predominantly found in transglutaminase and transglutaminase-like proteins. Their exact function is, as yet, unknown, but they are likely to act as amidoligase enzymes [[cite:PUB00053382]] Protein in this family are found in conserved gene neighborhoods encoding a glutamine amidotransferase-like thiol peptidase (in proteobacteria) or an Aig2 family cyclotransferase protein (in firmicutes) [[cite:PUB00053382]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00053382":{"PMID":18980670,"ISBN":null,"volume":"3","issue":null,"year":2008,"title":"Unraveling the biochemistry and provenance of pupylation: a prokaryotic analog of ubiquitination.","URL":null,"raw_pages":"45","medline_journal":"Biol Direct","ISO_journal":"Biol. Direct","authors":["Iyer LM","Burroughs AM","Aravind L."],"DOI_URL":"http://dx.doi.org/10.1186/1745-6150-3-45"}},"set_info":{"accession":"CL0286","name":"GCS"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":11,"interactions":0,"matches":3483,"pathways":0,"proteins":3222,"proteomes":3132,"sets":1,"structural_models":{"alphafold":2055},"structures":0,"taxa":4574},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":77,"alignment:full":1794},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}