{"metadata":{"accession":"PF09873","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR016736","hierarchy":null,"name":{"name":"SepCysE-like","short":"SepCysE"},"description":[{"text":"<p>This family includes MJ1481 from Methanocaldococcus jannaschii and similar archaeal proteins. MJ1481 has been reported to be SepCysE, a translation factor, essential for the methanococcal Cys biosynthesis. SepCysE forms a bridge between Sep-tRNA:Cys -tRNA synthase (SepCysS) and O-phosphoseryl-tRNA synthetase (SepRS), forming the transsulfursome complex, enabling substrate channelling of Sep-tRNACys [[cite:PUB00093677],[cite:PUB00093676]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00093677":{"PMID":29142195,"ISBN":null,"volume":"8","issue":"1","year":2017,"title":"Structural basis for tRNA-dependent cysteine biosynthesis.","URL":null,"raw_pages":"1521","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Chen M","Kato K","Kubo Y","Tanaka Y","Liu Y","Long F","Whitman WB","Lill P","Gatsogiannis C","Raunser S","Shimizu N","Shinoda A","Nakamura A","Tanaka I","Yao M."],"DOI_URL":null},"PUB00093676":{"PMID":25002468,"ISBN":null,"volume":"111","issue":"29","year":2014,"title":"Ancient translation factor is essential for tRNA-dependent cysteine biosynthesis in methanogenic archaea.","URL":null,"raw_pages":"10520-5","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Liu Y","Nakamura A","Nakazawa Y","Asano N","Ford KA","Hohn MJ","Tanaka I","Yao M","Soll D."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":38,"pathways":0,"proteins":38,"proteomes":38,"sets":0,"structural_models":{"alphafold":35},"structures":4,"taxa":82},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":18},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}