{"metadata":{"accession":"PF09867","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR017748","hierarchy":null,"name":{"name":"TagF N-terminal domain, Type VI secretion system-associated","short":"TagF_N"},"description":[{"text":"<p>This is the N-terminal domain of the T6S-associated protein, TagF. A post-translational repressor of the hemolysin co-regulated secretion island I (HSI-I)-encoded type VI secretion system (H1-T6SS) found in Pseudomonas aeruginosa. The type VI secretion system (T6SS) is found broadly among the Proteobacteria and is implicated in diverse processes including host-cell interactions, biofilm formation and gene regulation. Furthermore, studies indicate that the T6SS plays a critical role in interbacterial interactions. TagF has been shown to regulate the activity of the H1-T6SS in a manner that does not require phosphorylated-Fha1, PpkA, or other Tag proteins. Additionally TagF is found to associate as a homodimer with nearly identical monomers composed of alpha and beta elements assembled as a three-layer sandwich (alpha-beta-alpha) [[cite:PUB00086563]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00086563":{"PMID":22017253,"ISBN":null,"volume":"82","issue":"5","year":2011,"title":"Separate inputs modulate phosphorylation-dependent and -independent type VI secretion activation.","URL":null,"raw_pages":"1277-90","medline_journal":"Mol Microbiol","ISO_journal":"Mol. Microbiol.","authors":["Silverman JM","Austin LS","Hsu F","Hicks KG","Hood RD","Mougous JD."],"DOI_URL":"https://doi.org/10.1111/j.1365-2958.2011.07889.x"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":9,"interactions":0,"matches":2312,"pathways":0,"proteins":2309,"proteomes":1976,"sets":0,"structural_models":{"alphafold":1373},"structures":3,"taxa":2835},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":36,"alignment:full":867},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}