{"metadata":{"accession":"PF09847","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018646","hierarchy":null,"name":{"name":"Membrane protein of 12 TMs","short":"12TM_1"},"description":[{"text":"<p>This family carries twelve transmembrane regions. It does not have any characteristic nucleotide-binding-domains of the GxSGSGKST type. so it may not be an ATP-binding cassette transporter. However, it may well be a transporter of some description. ABC transporters always have two nucleotide binding domains; this has two unusual conserved sequence-motifs: 'KDhKxhhR' and 'LxxLP'.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":null,"set_info":{"accession":"CL0181","name":"ABC-2"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":429,"pathways":0,"proteins":429,"proteomes":404,"sets":1,"structural_models":{"alphafold":313},"structures":0,"taxa":835},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":18,"alignment:full":253},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}