{"metadata":{"accession":"PF09845","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018645","hierarchy":null,"name":{"name":"Origin-associated protein OapC","short":"OapC"},"description":[{"text":"<p>This entry includes archaeal Zinc-ribbon containing proteins which are mostly uncharacterised. Some members of this entry have been described as OapC/ArvC, encoded by oapC gene which is part of the three-gene cluster oapABC, involved in generation of extracellular vesicles (arv, archaeal vesiculating GTAse). Knockout of OapC/ArvC leads to over vesiculation, possibly due to dysregulation of OapA/ArvA, a small GTPase, therefore, it has been suggested that OapC/ArvC may represent a GAP [[cite:PUB00154442],[cite:PUB00154443]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00154443":{"PMID":38408251,"ISBN":null,"volume":"121","issue":"10","year":2024,"title":"Extracellular vesicle formation in <i>Euryarchaeota</i> is driven by a small GTPase.","URL":null,"raw_pages":"e2311321121","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Mills J","Gebhard LJ","Schubotz F","Shevchenko A","Speth DR","Liao Y","Duggin IG","Marchfelder A","Erdmann S."],"DOI_URL":"https://doi.org/10.1073/pnas.2311321121"},"PUB00154442":{"PMID":31769790,"ISBN":null,"volume":"366","issue":"21","year":2019,"title":"Bioinformatic and genetic characterization of three genes localized adjacent to the major replication origin of Haloferax volcanii.","URL":null,"raw_pages":"fnz238","medline_journal":"FEMS Microbiol Lett","ISO_journal":"FEMS Microbiol Lett","authors":["Wolters M","Borst A","Pfeiffer F","Soppa J."],"DOI_URL":"https://doi.org/10.1093/femsle/fnz238"}},"set_info":{"accession":"CL0167","name":"Zn_Beta_Ribbon"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":617,"pathways":0,"proteins":423,"proteomes":421,"sets":1,"structural_models":{"alphafold":394},"structures":0,"taxa":724},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":292},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}