This entry was previously the N terminal portion of DUF524 ([pfam:PF04411]) before it was split into two. This domain has no known function. It is predicted to adopt an all beta secondary structure pattern followed by mainly alpha-helical structures [[cite:PUB00044133]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00044133":{"PMID":17584917,"ISBN":null,"volume":"7","issue":null,"year":2007,"title":"Realm of PD-(D/E)XK nuclease superfamily revisited: detection of novel families with modified transitive meta profile searches.","URL":null,"raw_pages":"40","medline_journal":"BMC Struct Biol","ISO_journal":"BMC Struct. Biol.","authors":["Knizewski L","Kinch LN","Grishin NV","Rychlewski L","Ginalski K."],"DOI_URL":"http://dx.doi.org/10.1186/1472-6807-7-40"}},"set_info":{"accession":"CL0236","name":"PDDEXK"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":9,"interactions":0,"matches":1054,"pathways":0,"proteins":1051,"proteomes":988,"sets":1,"structural_models":{"alphafold":669},"structures":0,"taxa":2075},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":13,"alignment:full":541},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}