{"metadata":{"accession":"PF09817","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018630","hierarchy":null,"name":{"name":"RZZ complex, subunit zwilch","short":"Zwilch"},"description":[{"text":"<p>The protein Zwilch is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. It is required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores [[cite:PUB00054075],[cite:PUB00054076],[cite:PUB00044111]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00044111":{"PMID":17576797,"ISBN":null,"volume":"177","issue":"6","year":2007,"title":"Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore.","URL":null,"raw_pages":"1005-15","medline_journal":"J Cell Biol","ISO_journal":"J. Cell Biol.","authors":["Griffis ER","Stuurman N","Vale RD."],"DOI_URL":"http://dx.doi.org/10.1083/jcb.200702062"},"PUB00054076":{"PMID":15886105,"ISBN":null,"volume":"15","issue":"9","year":2005,"title":"Recruitment of Mad2 to the kinetochore requires the Rod/Zw10 complex.","URL":null,"raw_pages":"856-61","medline_journal":"Curr Biol","ISO_journal":"Curr. Biol.","authors":["Buffin E","Lefebvre C","Huang J","Gagou ME","Karess RE."],"DOI_URL":"http://dx.doi.org/10.1016/j.cub.2005.03.052"},"PUB00054075":{"PMID":12686595,"ISBN":null,"volume":"14","issue":"4","year":2003,"title":"Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.","URL":null,"raw_pages":"1379-91","medline_journal":"Mol Biol Cell","ISO_journal":"Mol. Biol. Cell","authors":["Williams BC","Li Z","Liu S","Williams EV","Leung G","Yen TJ","Goldberg ML."],"DOI_URL":"http://dx.doi.org/10.1091/mbc.E02-09-0624"}},"set_info":{"accession":"CL0273","name":"CYTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":30,"interactions":0,"matches":1618,"pathways":0,"proteins":1533,"proteomes":1131,"sets":1,"structural_models":{"alphafold":1347},"structures":2,"taxa":3705},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":1311},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}