{"metadata":{"accession":"PF09745","entry_id":null,"type":"coiled_coil","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018612","hierarchy":null,"name":{"name":"Nuclear speckle splicing regulatory protein 1, N-terminal","short":"NSRP1_N"},"description":[{"text":"<p>This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation [[cite:PUB00093376],[cite:PUB00093375]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00093376":{"PMID":21296756,"ISBN":null,"volume":"39","issue":"10","year":2011,"title":"NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo.","URL":null,"raw_pages":"4300-14","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Kim YD","Lee JY","Oh KM","Araki M","Araki K","Yamamura K","Jun CD."],"DOI_URL":null},"PUB00093375":{"PMID":26797131,"ISBN":null,"volume":"291","issue":"12","year":2016,"title":"Nuclear Speckle-related Protein 70 Binds to Serine/Arginine-rich Splicing Factors 1 and 2 via an Arginine/Serine-like Region and Counteracts Their Alternative Splicing Activity.","URL":null,"raw_pages":"6169-81","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Kim CH","Kim YD","Choi EK","Kim HR","Na BR","Im SH","Jun CD."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":73,"interactions":0,"matches":3787,"pathways":0,"proteins":3772,"proteomes":3150,"sets":0,"structural_models":{"alphafold":3230},"structures":0,"taxa":8427},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":113,"alignment:full":2882},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}