{"metadata":{"accession":"PF09741","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":null,"hierarchy":null,"name":{"name":"Uncharacterized conserved protein (DUF2045)","short":"DUF2045"},"description":[{"text":"<p>This entry represents Uncharacterized protein KIAA0930 homolog found in animals. KIAA0930 is localised in the cytosol and not secreted from cells. Expression of KIAA0930 (C22orf9) is significantly higher in pancreatic, colorectal, gastric, and tongue cancer tissues than in normal tissues [[cite:PUB00163385]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00163385":{"PMID":37477523,"ISBN":null,"volume":"14","issue":null,"year":2023,"title":"The uncharacterized transcript <i>KIAA0930</i> confers a cachexic phenotype on cancer cells.","URL":null,"raw_pages":"723-737","medline_journal":"Oncotarget","ISO_journal":"Oncotarget","authors":["Yamakawa T","Zhang G","Najjar LB","Li C","Itakura K."],"DOI_URL":"https://doi.org/10.18632/oncotarget.28476"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":52,"interactions":0,"matches":2841,"pathways":0,"proteins":2724,"proteomes":1472,"sets":0,"structural_models":{"alphafold":2265},"structures":0,"taxa":4691},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":19,"alignment:full":2041},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}