{"metadata":{"accession":"PF09724","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019128","hierarchy":null,"name":{"name":"Sister chromatid cohesion protein Dcc1","short":"Dcc1"},"description":[{"text":"<p>Sister chromatid cohesion protein Dcc1 is a component of the Ctf18-RFC complex. This complex is required for the efficient establishment of chromosome cohesion during S-phase and for loading the replication clamp Pol30/PCNA, which functions in DNA replication and repair [[cite:PUB00045276],[cite:PUB00109231]]. Ctf18-RFC loads PCNA onto DNA in an ATP-dependent manner. It may also have PCNA-unloading activity [[cite:PUB00045277]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00045277":{"PMID":15964801,"ISBN":null,"volume":"25","issue":"13","year":2005,"title":"Replication protein A-directed unloading of PCNA by the Ctf18 cohesion establishment complex.","URL":null,"raw_pages":"5445-55","medline_journal":"Mol Cell Biol","ISO_journal":"Mol. Cell. Biol.","authors":["Bylund GO","Burgers PM."],"DOI_URL":"http://dx.doi.org/10.1128/MCB.25.13.5445-5455.2005"},"PUB00109231":{"PMID":12930902,"ISBN":null,"volume":"100","issue":"18","year":2003,"title":"The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA.","URL":null,"raw_pages":"10237-42","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Bermudez VP","Maniwa Y","Tappin I","Ozato K","Yokomori K","Hurwitz J."],"DOI_URL":null},"PUB00045276":{"PMID":11389843,"ISBN":null,"volume":"7","issue":"5","year":2001,"title":"Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae.","URL":null,"raw_pages":"959-70","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Mayer ML","Gygi SP","Aebersold R","Hieter P."],"DOI_URL":"http://dx.doi.org/10.1016/S1097-2765(01)00254-4"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":68,"interactions":0,"matches":3816,"pathways":0,"proteins":3718,"proteomes":3182,"sets":0,"structural_models":{"alphafold":3143},"structures":9,"taxa":8443},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":103,"alignment:full":2868},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}