{"metadata":{"accession":"PF09722","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024467","hierarchy":null,"name":{"name":"Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain","short":"Xre_MbcA_ParS_C"},"description":[{"text":"<p>This entry represents the C-terminal domain of antitoxin components of a type II toxin-antitoxin (TA) system, including Xre from Pseudomonas putida, MbcA from Mycobacterium sp. and ParS from Sphingobium sp. [[cite:PUB00098292],[cite:PUB00098291],[cite:PUB00093678],[cite:PUB00098290]]. This domain interacts with the toxin component and sterically blocks its active site, neutralising its effect [[cite:PUB00098291],[cite:PUB00093678]]. These antitoxins also have a HTH domain at the N-terminal.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00098290":{"PMID":33384857,"ISBN":null,"volume":"19","issue":null,"year":2021,"title":"Bacterial type II toxin-antitoxin systems acting through post-translational modifications.","URL":null,"raw_pages":"86-93","medline_journal":"Comput Struct Biotechnol J","ISO_journal":"Comput Struct Biotechnol J","authors":["Zhang SP","Feng HZ","Wang Q","Kempher ML","Quan SW","Tao X","Niu S","Wang Y","Feng HY","He YX."],"DOI_URL":null},"PUB00098292":{"PMID":30598453,"ISBN":null,"volume":"116","issue":"3","year":2019,"title":"ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism.","URL":null,"raw_pages":"826-834","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Piscotta FJ","Jeffrey PD","Link AJ."],"DOI_URL":null},"PUB00098291":{"PMID":30792174,"ISBN":null,"volume":"73","issue":"6","year":2019,"title":"An NAD<sup>+</sup> Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death.","URL":null,"raw_pages":"1282-1291.e8","medline_journal":"Mol Cell","ISO_journal":"Mol Cell","authors":["Freire DM","Gutierrez C","Garza-Garcia A","Grabowska AD","Sala AJ","Ariyachaokun K","Panikova T","Beckham KSH","Colom A","Pogenberg V","Cianci M","Tuukkanen A","Boudehen YM","Peixoto A","Botella L","Svergun DI","Schnappinger D","Schneider TR","Genevaux P","de Carvalho LPS","Wilmanns M","Parret AHA","Neyrolles O."],"DOI_URL":null},"PUB00093678":{"PMID":30315706,"ISBN":null,"volume":"111","issue":"1","year":2019,"title":"The RES domain toxins of RES-Xre toxin-antitoxin modules induce cell stasis by degrading NAD+","URL":null,"raw_pages":"221-236","medline_journal":"Mol Microbiol","ISO_journal":"Mol. Microbiol.","authors":["Skjerning RB","Senissar M","Winther KS","Gerdes K","Brodersen DE."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":40,"interactions":0,"matches":7333,"pathways":0,"proteins":7332,"proteomes":4456,"sets":0,"structural_models":{"alphafold":4658},"structures":8,"taxa":6594},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":136,"alignment:full":3324},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6d0h","name":"ParT: Prs ADP-ribosylating toxin bound to cognate antitoxin ParS"}}}