The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc [[cite:PUB00053439]] has been extended to become this six-helical PRESAN domain identified in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera, suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium undergoing a dramatic proliferation only in P. falciparum. A secondary structure-prediction derived from the multiple alignment of the PRESAN family reveals that it is composed of an all-helical fold with six conserved helical segments. There is some evidence it might localise to membranes [[cite:PUB00055558]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Plasmodium_helical_interspersed_subtelomeric_protein","extract":"The Plasmodium helical interspersed subtelomeric proteins (PHIST) or ring-infected erythrocyte surface antigens (RESA) are a family of protein domains found in the malaria-causing Plasmodium species. It was initially identified as a short four-helical conserved region in the single-domain export proteins, but the identification of this part associated with a DnaJ domain in P. falciparum RESA has led to its reclassification as the RESA N-terminal domain. This domain has been classified into three subfamilies, PHISTa, PHISTb, and PHISTc.
","thumbnail":null}],"literature":{"PUB00055558":{"PMID":17283083,"ISBN":null,"volume":"75","issue":"4","year":2007,"title":"Molecular factors and biochemical pathways induced by febrile temperature in intraerythrocytic Plasmodium falciparum parasites.","URL":null,"raw_pages":"2012-25","medline_journal":"Infect Immun","ISO_journal":"Infect. Immun.","authors":["Oakley MS","Kumar S","Anantharaman V","Zheng H","Mahajan B","Haynes JD","Moch JK","Fairhurst R","McCutchan TF","Aravind L."],"DOI_URL":"http://dx.doi.org/10.1128/IAI.01236-06"},"PUB00053439":{"PMID":16507167,"ISBN":null,"volume":"7","issue":"2","year":2006,"title":"Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites.","URL":null,"raw_pages":"R12","medline_journal":"Genome Biol","ISO_journal":"Genome Biol.","authors":["Sargeant TJ","Marti M","Caler E","Carlton JM","Simpson K","Speed TP","Cowman AF."],"DOI_URL":"http://dx.doi.org/10.1186/gb-2006-7-2-r12"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":10,"interactions":0,"matches":867,"pathways":0,"proteins":854,"proteomes":25,"sets":0,"structural_models":{"alphafold":751},"structures":2,"taxa":93},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":140,"alignment:full":1158},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"7d2w","name":"Crystal structure of PHIT/PHISTa-like subfamily PF3D7_1372300 protein from plasmodium falciparum"}}}