This domain is found in found in uncharacterised proteins predominantly from bacteria. The uncharacterised [swissprot:Q9I1U6] from Pseudomonas aeruginosa shows a ferritin-like topology with a four-helix-bundle fold that lacks metal-ion-binding site typical of the ferritin family ([pfam:PF00210]) but has a potential metal-binding site [[cite:PUB00065044]]. The function is unknown.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00065044":{"PMID":23295481,"ISBN":null,"volume":"69","issue":"Pt 1","year":2013,"title":"The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery.","URL":null,"raw_pages":"25-34","medline_journal":"Acta Crystallogr Sect F Struct Biol Cryst Commun","ISO_journal":"Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.","authors":["Moynie L","Schnell R","McMahon SA","Sandalova T","Boulkerou WA","Schmidberger JW","Alphey M","Cukier C","Duthie F","Kopec J","Liu H","Jacewicz A","Hunter WN","Naismith JH","Schneider G."],"DOI_URL":"http://dx.doi.org/10.1107/S1744309112044739"}},"set_info":{"accession":"CL0044","name":"Ferritin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":12,"interactions":0,"matches":5046,"pathways":0,"proteins":5046,"proteomes":3489,"sets":1,"structural_models":{"alphafold":3179},"structures":1,"taxa":5006},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":32,"alignment:full":2286},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}