{"metadata":{"accession":"PF09495","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019034","hierarchy":null,"name":{"name":"Protein of unknown function (DUF2462)","short":"DUF2462"},"description":[{"text":"<p>This protein is highly conserved, but its function is unknown. It can be isolated from HeLa cell nucleoli and is found to be homologous with Leydig cell tumour protein whose function is unknown [1, supplementary Table I].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00044959":{"PMID":15635413,"ISBN":null,"volume":"433","issue":"7021","year":2005,"title":"Nucleolar proteome dynamics.","URL":null,"raw_pages":"77-83","medline_journal":"Nature","ISO_journal":"Nature","authors":["Andersen JS","Lam YW","Leung AK","Ong SE","Lyon CE","Lamond AI","Mann M."],"DOI_URL":"http://dx.doi.org/10.1038/nature03207"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":42,"interactions":0,"matches":2783,"pathways":0,"proteins":2773,"proteomes":2494,"sets":0,"structural_models":{"alphafold":2360},"structures":7,"taxa":6695},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":95,"alignment:full":2078},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}