Acid-adaptive protein possibly of physiological significance when H.pylori colonises the human stomach, which adopts a unique four alpha-helical triangular conformations. The biologically active form is thought to be a tetramer. The protein is expressed along with six other proteins, some of which are related to iron storage and haem biosynthesis [[cite:PUB00039697]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00039697":{"PMID":16395670,"ISBN":null,"volume":"62","issue":"4","year":2006,"title":"Crystal structure of HP0242, a hypothetical protein from Helicobacter pylori with a novel fold.","URL":null,"raw_pages":"1138-43","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Tsai JY","Chen BT","Cheng HC","Chen HY","Hsaio NW","Lyu PC","Sun YJ."],"DOI_URL":"http://dx.doi.org/10.1002/prot.20864"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":172,"pathways":0,"proteins":172,"proteomes":172,"sets":0,"structural_models":{"alphafold":132},"structures":5,"taxa":271},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":70,"alignment:full":77},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4u12","name":"Crystal structure of protein HP0242 from Helicobacter pylori at 1.94 A resolution: a knotted homodimer"}}}