{"metadata":{"accession":"PF09438","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018561","hierarchy":null,"name":{"name":"Domain of unknown function (DUF2017)","short":"DUF2017"},"description":[{"text":"<p>This is an alpha-helical domain found in gene neighborhoods that contain genes encoding ubiquitin, cysteine synthases and JAB peptidases [[cite:PUB00034476]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00034476":{"PMID":16859499,"ISBN":null,"volume":"7","issue":"7","year":2006,"title":"The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like beta-grasp domains.","URL":null,"raw_pages":"R60","medline_journal":"Genome Biol","ISO_journal":"Genome Biol.","authors":["Iyer LM","Burroughs AM","Aravind L."],"DOI_URL":"http://dx.doi.org/10.1186/gb-2006-7-7-r60"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":3823,"pathways":0,"proteins":3819,"proteomes":3718,"sets":0,"structural_models":{"alphafold":2231},"structures":0,"taxa":4448},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":380,"alignment:full":1883},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}