A predicted alpha+beta domain that is usually fused N-terminal to the JAB metallopeptidase. This protein in turn is found in conserved gene neighborhoods that include genes encoding the bacterial homologs of the ubiquitin modification system such as the E1, E2 and Ub proteins [[cite:PUB00034476]]. The domain is also known as the JAB-N domain. An AlphaFold3 prediction with A0A375JCV4 suggests that this domain likely mediate dimerisation (iPTM=0.87).
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00034476":{"PMID":16859499,"ISBN":null,"volume":"7","issue":"7","year":2006,"title":"The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like beta-grasp domains.","URL":null,"raw_pages":"R60","medline_journal":"Genome Biol","ISO_journal":"Genome Biol.","authors":["Iyer LM","Burroughs AM","Aravind L."],"DOI_URL":"http://dx.doi.org/10.1186/gb-2006-7-7-r60"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":204,"pathways":0,"proteins":204,"proteomes":181,"sets":0,"structural_models":{"alphafold":135},"structures":0,"taxa":326},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":62,"alignment:full":107},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}