This domain is found at the C terminal of a family of ER membrane bound transcription factors called sterol regulatory element binding proteins (SREBP).
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00044954":{"PMID":15797383,"ISBN":null,"volume":"120","issue":"6","year":2005,"title":"SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast.","URL":null,"raw_pages":"831-42","medline_journal":"Cell","ISO_journal":"Cell","authors":["Hughes AL","Todd BL","Espenshade PJ."],"DOI_URL":"http://dx.doi.org/10.1016/j.cell.2005.01.012"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":11,"interactions":0,"matches":936,"pathways":0,"proteins":920,"proteomes":882,"sets":0,"structural_models":{"alphafold":752},"structures":2,"taxa":1757},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":36,"alignment:full":742},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}