{"metadata":{"accession":"PF09419","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR027706","hierarchy":null,"name":{"name":"Mitochondrial PGP phosphatase","short":"PGP_phosphatase"},"description":[{"text":"<p>This is a family of proteins that acts as a mitochondrial phosphatase in cardiolipin biosynthesis. Cardiolipin is a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes. The inverted phosphatase motif includes the highly conserved DKD triad [[cite:PUB00066452]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00066452":{"PMID":20485265,"ISBN":null,"volume":"29","issue":"12","year":2010,"title":"A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4.","URL":null,"raw_pages":"1976-87","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Osman C","Haag M","Wieland FT","Brugger B","Langer T."],"DOI_URL":"http://dx.doi.org/10.1038/emboj.2010.98"}},"set_info":{"accession":"CL0137","name":"HAD"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":40,"interactions":0,"matches":2666,"pathways":0,"proteins":2628,"proteomes":2267,"sets":1,"structural_models":{"alphafold":2133},"structures":0,"taxa":5136},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":1950},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}