This is a family of proteins with unknown function. The structure of one of the proteins in this family has revealed a novel alpha-beta fold [[cite:PUB00039229]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00039229":{"PMID":16374782,"ISBN":null,"volume":"62","issue":"3","year":2006,"title":"NMR structure of the conserved novel-fold protein TA0743 from Thermoplasma acidophilum.","URL":null,"raw_pages":"819-21","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Kim B","Jung J","Hong E","Yee A","Arrowsmith CH","Lee W."],"DOI_URL":"http://dx.doi.org/10.1002/prot.20832"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":10,"pathways":0,"proteins":10,"proteomes":9,"sets":0,"structural_models":{"alphafold":10},"structures":1,"taxa":30},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":6},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}