{"metadata":{"accession":"PF09346","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018958","hierarchy":null,"name":{"name":"SMI1 / KNR4 family (SUKH-1)","short":"SMI1_KNR4"},"description":[{"text":"<p>Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation [[cite:PUB00044491]][[cite:PUB00013613]]. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems [[cite:PUB00057479]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00013613":{"PMID":8289782,"ISBN":null,"volume":"14","issue":"2","year":1994,"title":"Cloning and characterization of KNR4, a yeast gene involved in (1,3)-beta-glucan synthesis.","URL":null,"raw_pages":"1017-25","medline_journal":"Mol Cell Biol","ISO_journal":"Mol. Cell. Biol.","authors":["Hong Z","Mann P","Brown NH","Tran LE","Shaw KJ","Hare RS","DiDomenico B."],"DOI_URL":"http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=8289782"},"PUB00057479":{"PMID":21306995,"ISBN":null,"volume":"39","issue":"11","year":2011,"title":"A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems.","URL":null,"raw_pages":"4532-52","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Zhang D","Iyer LM","Aravind L."],"DOI_URL":"http://dx.doi.org/10.1093/nar/gkr036"},"PUB00044491":{"PMID":7937796,"ISBN":null,"volume":"91","issue":"20","year":1994,"title":"Cloning and characterization of a Neurospora crassa gene required for (1,3) beta-glucan synthase activity and cell wall formation.","URL":null,"raw_pages":"9500-4","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Enderlin CS","Selitrennikoff CP."],"DOI_URL":"http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=7937796"}},"set_info":{"accession":"CL0526","name":"SUKH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":161,"interactions":0,"matches":16505,"pathways":0,"proteins":16439,"proteomes":7667,"sets":1,"structural_models":{"alphafold":9960},"structures":11,"taxa":13858},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":148,"alignment:full":8256},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3d5p","name":"CRYSTAL STRUCTURE OF A PUTATIVE GLUCAN SYNTHESIS REGULATOR OF SMI1/KNR4 FAMILY (BF1740) FROM BACTEROIDES FRAGILIS NCTC 9343 AT 1.45 A RESOLUTION"}}}