{"metadata":{"accession":"PF09345","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018530","hierarchy":null,"name":{"name":"SiaC family regulatory phosphoprotein","short":"SiaC"},"description":[{"text":"<p>This entry represents the SiaC family regulatory phosphoprotein which undergoes a regulatory phosphorylation at Thr-68 of founder protein PA0170 from Pseudomonas aeruginosa, but in more distant homologs, T can be S. Also, it is part of motif NTSS, so may contain more than one phosphorylation site. Phosphorylation causes regulatory change to protein-protein interaction, in a pathway that seems broadly distributed, involves a diguanylate cyclase, and in the case of Pseudomonas aeruginosa affects aggregation and biofilm formation responses.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00098623":{"PMID":33156827,"ISBN":null,"volume":"15","issue":"11","year":2020,"title":"The SiaABC threonine phosphorylation pathway controls biofilm formation in response to carbon availability in Pseudomonas aeruginosa.","URL":null,"raw_pages":"e0241019","medline_journal":"PLoS One","ISO_journal":"PLoS One","authors":["Poh WH","Lin J","Colley B","Muller N","Goh BC","Schleheck D","El Sahili A","Marquardt A","Liang Y","Kjelleberg S","Lescar J","Rice SA","Klebensberger J."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":1368,"pathways":0,"proteins":1367,"proteomes":970,"sets":0,"structural_models":{"alphafold":984},"structures":4,"taxa":1698},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":118,"alignment:full":818},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6k4f","name":"SiaC of Pseudomonas aeruginosa"}}}