{"metadata":{"accession":"PF09324","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR015403","hierarchy":null,"name":{"name":"Mon2/Sec7/BIG1-like, HDS","short":"Sec7-like_HDS"},"description":[{"text":"<p>This entry represents a HDS (homology downstream of Sec7) domain found towards the C-terminal of guanine nucleotide exchange factors involved Golgi transport, such as budding yeast protein Sec7, protein Mon2 and BIG1-like proteins [[cite:PUB00101185],[cite:PUB00101184]]. Sec7 is involved in the secretory pathway as a protein binding scaffold for the COPII-COPI protein switch for maturation of the VTC intermediate compartments for Golgi compartment biogenesis [[cite:PUB00076747]]. Sec7 has four HDS1-4 domains, which act to integrate the signals from several small GTPases, including Arf1 itself, to switch Sec7 from a strongly autoinhibited to a strongly auto activated form [[cite:PUB00101184]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00076747":{"PMID":11208097,"ISBN":null,"volume":"1","issue":"2","year":2000,"title":"Sec7p directs the transitions required for yeast Golgi biogenesis.","URL":null,"raw_pages":"172-83","medline_journal":"Traffic","ISO_journal":"Traffic","authors":["Deitz SB","Rambourg A","Kepes F","Franzusoff A."],"DOI_URL":"http://dx.doi.org/10.1034/j.1600-0854.2000.010209.x"},"PUB00101184":{"PMID":26765562,"ISBN":null,"volume":"5","issue":null,"year":2016,"title":"The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase. ","URL":null,"raw_pages":"e12411","medline_journal":"Elife","ISO_journal":"Elife","authors":["Richardson BC","Halaby SL","Gustafson MA","Fromme JC."],"DOI_URL":null},"PUB00101185":{"PMID":27373159,"ISBN":null,"volume":"16","issue":"3","year":2016,"title":"Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi.","URL":null,"raw_pages":"839-50","medline_journal":"Cell Rep","ISO_journal":"Cell Rep","authors":["Galindo A","Soler N","McLaughlin SH","Yu M","Williams RL","Munro S."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":230,"interactions":0,"matches":12422,"pathways":0,"proteins":12400,"proteomes":3349,"sets":0,"structural_models":{"alphafold":1000},"structures":1,"taxa":8869},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":91,"alignment:full":9354},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}