{"metadata":{"accession":"PF09313","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR015392","hierarchy":null,"name":{"name":"TehB-like domain","short":"TehB-like"},"description":[{"text":"<p>This domain, previously known as DUF1971, is found at the N-terminal associated with [pfam:PF03848], and covering the whole length of the sequence in other bacterial uncharacterised proteins. TehB plays a role in both resistance to oxidative damage and haem uptake/utilisation, and is important for virulence of this organism in an animal model of invasive disease. It also protects H.influenzae from tellurite exposure in vitro [[cite:PUB00161042]]. In Escherichia coli, TehB is thought to utilise a methyltransferase activity in the detoxification of tellurite [[cite:PUB00014885]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00014885":{"PMID":11053398,"ISBN":null,"volume":"182","issue":"22","year":2000,"title":"Escherichia coli TehB requires S-adenosylmethionine as a cofactor to mediate tellurite resistance.","URL":null,"raw_pages":"6509-13","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Liu M","Turner RJ","Winstone TL","Saetre A","Dyllick-Brenzinger M","Jickling G","Tari LW","Weiner JH","Taylor DE."],"DOI_URL":"http://dx.doi.org/10.1128/JB.182.22.6509-6513.2000"},"PUB00161042":{"PMID":20075041,"ISBN":null,"volume":"156","issue":"Pt 4","year":2010,"title":"Characterization of the Haemophilus influenzae tehB gene and its role in virulence.","URL":null,"raw_pages":"1188-1200","medline_journal":"Microbiology (Reading)","ISO_journal":"Microbiology (Reading)","authors":["Whitby PW","Seale TW","Morton DJ","VanWagoner TM","Stull TL."],"DOI_URL":"https://doi.org/10.1099/mic.0.036400-0"}},"set_info":{"accession":"CL0029","name":"Cupin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":13,"interactions":0,"matches":1552,"pathways":0,"proteins":1552,"proteomes":1261,"sets":1,"structural_models":{"alphafold":1007},"structures":3,"taxa":2093},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":34,"alignment:full":581},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}