Members of this family contain a four-stranded beta sheet and three alpha helices flanked by an additional beta strand. They are predominantly found in the bacterial GTP-binding protein Obg, and are still functionally uncharacterised [[cite:PUB00022779]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00022779":{"PMID":15019792,"ISBN":null,"volume":"337","issue":"3","year":2004,"title":"Crystal structure of the GTP-binding protein Obg from Thermus thermophilus HB8.","URL":null,"raw_pages":"761-70","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Kukimoto-Niino M","Murayama K","Inoue M","Terada T","Tame JR","Kuramitsu S","Shirouzu M","Yokoyama S."],"DOI_URL":"http://dx.doi.org/10.1016/j.jmb.2004.01.047"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":29,"interactions":0,"matches":8360,"pathways":0,"proteins":8357,"proteomes":8086,"sets":0,"structural_models":{"alphafold":5385},"structures":1,"taxa":11853},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":237,"alignment:full":4403},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}