{"metadata":{"accession":"PF09199","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR015282","hierarchy":null,"name":{"name":"Staphylococcal superantigen-like OB-fold domain","short":"SSL_OB"},"description":[{"text":"<p>This OB-fold domain folds into a five-stranded beta-barrel [[cite:PUB00018994]]. Members of this family are found in various staphylococcal toxins described as staphylococcal superantigen-like (SSL) proteins that are related to the staphylococcal enterotoxins (SEs) or superantigens. These SSL proteins of which 11 have so far been characterised have a typical SE tertiary structure consisting of a distinct oligonucleotide/oligosaccharide binding (OB-fold), this domain, linked to a beta-grasp domain, family Stap_Strp_tox_C, [pfam:PF02876]. SSLs do not bind to T-cell receptors or major histocompatibility complex class II molecules and do not stimulate T cells. SSLs target components of innate immunity, such as complement, Fc receptors, and myeloid cells 2,3,4,5,6,7,8]. SSL protein 7 (SSL7) is the best characterised of the SSLs and binds complement factor C5 and IgA with high affinity and inhibits the end stage of complement activation and IgA binding to FcalphaR [[cite:PUB00065773]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075648":{"PMID":20133685,"ISBN":null,"volume":"107","issue":"8","year":2010,"title":"Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus.","URL":null,"raw_pages":"3681-6","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Laursen NS","Gordon N","Hermans S","Lorenz N","Jackson N","Wines B","Spillner E","Christensen JB","Jensen M","Fredslund F","Bjerre M","Sottrup-Jensen L","Fraser JD","Andersen GR."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0910565107"},"PUB00049331":{"PMID":18045383,"ISBN":null,"volume":"66","issue":"6","year":2007,"title":"The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition.","URL":null,"raw_pages":"1342-55","medline_journal":"Mol Microbiol","ISO_journal":"Mol. Microbiol.","authors":["Chung MC","Wines BD","Baker H","Langley RJ","Baker EN","Fraser JD."],"DOI_URL":null},"PUB00048974":{"PMID":17848512,"ISBN":null,"volume":"104","issue":"38","year":2007,"title":"Structural basis for evasion of IgA immunity by Staphylococcus aureus revealed in the complex of SSL7 with Fc of human IgA1.","URL":null,"raw_pages":"15051-6","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Ramsland PA","Willoughby N","Trist HM","Farrugia W","Hogarth PM","Fraser JD","Wines BD."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0706028104"},"PUB00055800":{"PMID":21217642,"ISBN":null,"volume":"30","issue":"3","year":2011,"title":"Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.","URL":null,"raw_pages":"606-16","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Laursen NS","Andersen KR","Braren I","Spillner E","Sottrup-Jensen L","Andersen GR."],"DOI_URL":"http://dx.doi.org/10.1038/emboj.2010.341"},"PUB00049265":{"PMID":17996251,"ISBN":null,"volume":"374","issue":"5","year":2007,"title":"Crystal structures of the staphylococcal toxin SSL5 in complex with sialyl Lewis X reveal a conserved binding site that shares common features with viral and bacterial sialic acid binding proteins.","URL":null,"raw_pages":"1298-308","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Baker HM","Basu I","Chung MC","Caradoc-Davies T","Fraser JD","Baker EN."],"DOI_URL":"http://dx.doi.org/10.1016/j.jmb.2007.09.091"},"PUB00065773":{"PMID":22949551,"ISBN":null,"volume":"80","issue":"11","year":2012,"title":"Structural and functional properties of staphylococcal superantigen-like protein 4.","URL":null,"raw_pages":"4004-13","medline_journal":"Infect Immun","ISO_journal":"Infect. Immun.","authors":["Hermans SJ","Baker HM","Sequeira RP","Langley RJ","Baker EN","Fraser JD."],"DOI_URL":"http://dx.doi.org/10.1128/IAI.00764-12"},"PUB00018994":{"PMID":12082105,"ISBN":null,"volume":"277","issue":"35","year":2002,"title":"The Three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome.","URL":null,"raw_pages":"32274-81","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Arcus VL","Langley R","Proft T","Fraser JD","Baker EN."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M203914200"},"PUB00031971":{"PMID":15213171,"ISBN":null,"volume":"72","issue":"7","year":2004,"title":"Structural relationships and cellular tropism of staphylococcal superantigen-like proteins.","URL":null,"raw_pages":"4261-70","medline_journal":"Infect Immun","ISO_journal":"Infect. Immun.","authors":["Al-Shangiti AM","Naylor CE","Nair SP","Briggs DC","Henderson B","Chain BM."],"DOI_URL":"http://dx.doi.org/10.1128/IAI.72.7.4261-4270.2004"}},"set_info":{"accession":"CL0658","name":"OB_enterotoxin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":88,"pathways":0,"proteins":88,"proteomes":15,"sets":1,"structural_models":{"alphafold":76},"structures":31,"taxa":31},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":13},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}