{"metadata":{"accession":"PF09187","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR015270","hierarchy":null,"name":{"name":"RNA-directed DNA methylation 1","short":"RdDM_RDM1"},"description":[{"text":"<p>This family of plant proteins includes RDM1 from Arabidopsis, which is a component of the RNA-directed DNA methylation (RdDM) effector  complex and may have a role in linking siRNA production with  pre-existing or de novo cytosine methylation [[cite:PUB00057309]]. As part of the DDR complex with two other RdDM components, it has been shown to facilitate association of PolV to chromatin [[cite:PUB00109101],[cite:PUB00096469]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00096469":{"PMID":22864289,"ISBN":null,"volume":"19","issue":"9","year":2012,"title":"DDR complex facilitates global association of RNA polymerase V to promoters and evolutionarily young transposons.","URL":null,"raw_pages":"870-5","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat Struct Mol Biol","authors":["Zhong X","Hale CJ","Law JA","Johnson LM","Feng S","Tu A","Jacobsen SE."],"DOI_URL":null},"PUB00057309":{"PMID":20410883,"ISBN":null,"volume":"465","issue":"7294","year":2010,"title":"An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation.","URL":null,"raw_pages":"106-9","medline_journal":"Nature","ISO_journal":"Nature","authors":["Gao Z","Liu HL","Daxinger L","Pontes O","He X","Qian W","Lin H","Xie M","Lorkovic ZJ","Zhang S","Miki D","Zhan X","Pontier D","Lagrange T","Jin H","Matzke AJ","Matzke M","Pikaard CS","Zhu JK."],"DOI_URL":"http://dx.doi.org/10.1038/nature09025"},"PUB00109101":{"PMID":20409711,"ISBN":null,"volume":"20","issue":"10","year":2010,"title":"A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis.","URL":null,"raw_pages":"951-6","medline_journal":"Curr Biol","ISO_journal":"Curr Biol","authors":["Law JA","Ausin I","Johnson LM","Vashisht AA","Zhu JK","Wohlschlegel JA","Jacobsen SE."],"DOI_URL":null},"PUB00035392":{"PMID":16511118,"ISBN":null,"volume":"61","issue":"Pt 7","year":2005,"title":"Structure at 1.6 A resolution of the protein from gene locus At3g22680 from Arabidopsis thaliana.","URL":null,"raw_pages":"647-50","medline_journal":"Acta Crystallogr Sect F Struct Biol Cryst Commun","ISO_journal":"Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.","authors":["Allard ST","Bingman CA","Johnson KA","Wesenberg GE","Bitto E","Jeon WB","Phillips GN Jr."],"DOI_URL":"http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=16511118&action=stream&blobtype=pdf"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":14,"interactions":0,"matches":713,"pathways":0,"proteins":706,"proteomes":330,"sets":0,"structural_models":{"alphafold":560},"structures":5,"taxa":894},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":432},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2q3t","name":"Ensemble refinement of the protein crystal structure of gene product from Arabidopsis thaliana At3g22680"}}}