Members of this family pertain to a set of functionally uncharacterised hypothetical bacterial proteins. They adopt a ferredoxin-like fold, with a beta-alpha-beta-beta-alpha-beta arrangement [[cite:PUB00032088]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00032088":{"PMID":15103642,"ISBN":null,"volume":"55","issue":"3","year":2004,"title":"Crystal structure of YIGZ, a conserved hypothetical protein from Escherichia coli k12 with a novel fold.","URL":null,"raw_pages":"775-7","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Park F","Gajiwala K","Eroshkina G","Furlong E","He D","Batiyenko Y","Romero R","Christopher J","Badger J","Hendle J","Lin J","Peat T","Buchanan S."],"DOI_URL":"http://dx.doi.org/10.1002/prot.20087"}},"set_info":{"accession":"CL0437","name":"EF-G_C"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":8,"interactions":0,"matches":9056,"pathways":0,"proteins":9056,"proteomes":9028,"sets":1,"structural_models":{"alphafold":5636},"structures":2,"taxa":12454},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":91,"alignment:full":4130},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}