This entry represents the open beta-sheet domain found in vitellinogen, which generally corresponds to a domain within the lipovitellin-1 peptide product. This domain adopts a structure consisting of several large open beta-sheets [[cite:PUB00007158]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Vitellogenin","extract":"Vitellogenin is a precursor of the egg yolk proteins. It is synthesized and secreted by the liver of vertebrates, fat body of insects and the hepatopancreas of crustaceans. It is transported through the blood to be taken up by pinocytosis by the growing oocytes where it becomes incorporated into yolk granules. Normally, it is only found in the blood or hemolymph of females, and can therefore be used as a biomarker in vertebrates of exposure to environmental estrogens which stimulate elevated levels in males as well as females. \"Vg\" is a synonymous term for the vitellogenin gene and the expressed protein. The protein product is classified as a glyco-lipo-phospho-protein, having portions of sugar, fat and phosphate added post-translationally to the apo-protein in the tissue of origin. It belongs to a family of several lipid transport proteins.
","thumbnail":null}],"literature":{"PUB00007158":{"PMID":12135361,"ISBN":null,"volume":"41","issue":"30","year":2002,"title":"Lipid-protein interactions in lipovitellin.","URL":null,"raw_pages":"9398-409","medline_journal":"Biochemistry","ISO_journal":"Biochemistry","authors":["Thompson JR","Banaszak LJ."],"DOI_URL":"http://dx.doi.org/10.1021/bi025674w"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":344,"interactions":0,"matches":7489,"pathways":0,"proteins":7345,"proteomes":1241,"sets":0,"structural_models":{"alphafold":1444},"structures":11,"taxa":4626},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":87,"alignment:full":5264},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}