Members of this family of bacterial proteins assume a beta-sandwich structure consisting of two antiparallel beta-sheets similar to an immunoglobulin-like fold, with an additional small, antiparallel beta-sheet. The longer-stranded beta-sheet is made up of four antiparallel beta-strands. The shorter-stranded beta-sheet consists of five beta-strands, four of these beta-strands form an antiparallel beta-sheet. The exact function of this family of proteins is unknown, though a putative role includes involvement in host-bacterial interactions involved in endocytosis or phagocytosis, possibly during bacterial internalisation [[cite:PUB00028893]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00028893":{"PMID":12441386,"ISBN":null,"volume":"11","issue":"12","year":2002,"title":"Crystal structure of a major secreted protein of Mycobacterium tuberculosis-MPT63 at 1.5-A resolution.","URL":null,"raw_pages":"2887-93","medline_journal":"Protein Sci","ISO_journal":"Protein Sci.","authors":["Goulding CW","Parseghian A","Sawaya MR","Cascio D","Apostol MI","Gennaro ML","Eisenberg D."],"DOI_URL":"http://dx.doi.org/10.1110/ps.0219002"}},"set_info":{"accession":"CL0524","name":"MPT63-MPB63"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":554,"pathways":0,"proteins":552,"proteomes":249,"sets":1,"structural_models":{"alphafold":388},"structures":1,"taxa":292},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":13,"alignment:full":162},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1lmi","name":"1.5 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF A SECRETED PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS-MPT63"}}}