Members of this family are found in various Trypanosomatida hypothetical proteins, as well as in the cysteine protease calpain. Their exact function has not, as yet, been defined. This domain adopts a jelly-roll fold.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":11,"interactions":0,"matches":775,"pathways":0,"proteins":636,"proteomes":29,"sets":0,"structural_models":{"alphafold":590},"structures":2,"taxa":70},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":56,"alignment:full":406},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1r75","name":"Leishmania major hypothetical protein"}}}