Members of this family, which are found in a set of hypothetical bacterial proteins, contain a core of six alpha-helices, where one central helix is surrounded by the other five. The exact function of this family has not, as yet, been determined [[cite:PUB00035390]]. The known structure shows this domain contains two copies of the histone fold [[cite:PUB00035390]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00035390":{"PMID":16287087,"ISBN":null,"volume":"62","issue":"1","year":2006,"title":"The crystal structure of Aq_328 from the hyperthermophilic bacteria Aquifex aeolicus shows an ancestral histone fold.","URL":null,"raw_pages":"8-16","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Qiu Y","Tereshko V","Kim Y","Zhang R","Collart F","Yousef M","Kossiakoff A","Joachimiak A."],"DOI_URL":"http://dx.doi.org/10.1002/prot.20590"}},"set_info":{"accession":"CL0012","name":"Histone"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":566,"pathways":0,"proteins":566,"proteomes":528,"sets":1,"structural_models":{"alphafold":412},"structures":3,"taxa":919},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":19,"alignment:full":243},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1wwi","name":"Crystal structure of ttk003001566 from Thermus Thermophilus HB8"}}}