Members of this family are found in 3-mercaptopyruvate sulfurtransferase, and have no known function. They adopt a structure consisting of a four-stranded antiparallel beta-sheet and an alpha-helix, arranged in a beta(2)-alpha-beta(2) fashion, and bearing a remarkable structural similarity to the FK506-binding protein class of peptidylprolyl cis/trans-isomerase [[cite:PUB00029481]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00029481":{"PMID":12952945,"ISBN":null,"volume":"278","issue":"48","year":2003,"title":"The crystal structure of Leishmania major 3-mercaptopyruvate sulfurtransferase. A three-domain architecture with a serine protease-like triad at the active site.","URL":null,"raw_pages":"48219-27","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Alphey MS","Williams RA","Mottram JC","Coombs GH","Hunter WN."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M307187200"}},"set_info":{"accession":"CL0487","name":"FKBP"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":34,"pathways":0,"proteins":34,"proteomes":28,"sets":1,"structural_models":{"alphafold":31},"structures":1,"taxa":64},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":18},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}