This entry represents a putative zinc finger domain. Proteins containing this domain typically consist of a beta-sheet region followed by an alpha-helix and an unstructured C-terminus. The beta-sheet region contains a CXCX...XCXC sequence with Cys residues located in two proximal loops and pointing towards each other. The precise function of this set of bacterial proteins is, as yet, unknown [[cite:PUB00008047]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00008047":{"PMID":11017201,"ISBN":null,"volume":"7","issue":"10","year":2000,"title":"Structural proteomics of an archaeon.","URL":null,"raw_pages":"903-9","medline_journal":"Nat Struct Biol","ISO_journal":"Nat. Struct. Biol.","authors":["Christendat D","Yee A","Dharamsi A","Kluger Y","Savchenko A","Cort JR","Booth V","Mackereth CD","Saridakis V","Ekiel I","Kozlov G","Maxwell KL","Wu N","McIntosh LP","Gehring K","Kennedy MA","Davidson AR","Pai EF","Gerstein M","Edwards AM","Arrowsmith CH."],"DOI_URL":"http://dx.doi.org/10.1038/82823"}},"set_info":{"accession":"CL0167","name":"Zn_Beta_Ribbon"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":69,"pathways":0,"proteins":69,"proteomes":69,"sets":1,"structural_models":{"alphafold":57},"structures":1,"taxa":140},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":13,"alignment:full":37},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}