This short 71 residue domain is an HMG-box domain. HMG-box domains mediate re-modelling of chromatin-structure. Mammalian HMG-box proteins are of two types: those that are non-sequence-specific DNA-binding proteins with two HMG-box domains and a long highly acidic C-tail; and a diverse group of sequence-specific transcription factor-proteins with either a single HMG-box or up to six copies, and no acidic C-tail [[cite:PUB00109134]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"HMG-box","extract":"In molecular biology, the HMG-box is a protein domain which is involved in DNA binding. The domain is composed of approximately 75 amino acid residues that collectively mediate the DNA-binding of chromatin-associated high-mobility group proteins. HMG-boxes are present in many transcription factors and chromatin-remodeling complexes, where they can mediate non-sequence or sequence-specific DNA binding.
","thumbnail":null}],"literature":{"PUB00109134":{"PMID":17599239,"ISBN":null,"volume":"64","issue":"19-20","year":2007,"title":"The HMG-box: a versatile protein domain occurring in a wide variety of DNA-binding proteins.","URL":null,"raw_pages":"2590-606","medline_journal":"Cell Mol Life Sci","ISO_journal":"Cell Mol Life Sci","authors":["Stros M","Launholt D","Grasser KD."],"DOI_URL":null}},"set_info":{"accession":"CL0114","name":"HMG-box"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":287,"interactions":0,"matches":11403,"pathways":0,"proteins":11264,"proteomes":2442,"sets":1,"structural_models":{"alphafold":9007},"structures":45,"taxa":7266},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":8776},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3fgh","name":"Human mitochondrial transcription factor A box B"}}}