{"metadata":{"accession":"PF09005","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR015096","hierarchy":null,"name":{"name":"Far upstream element-binding protein, C-terminal","short":"FUBP_C"},"description":[{"text":"<p>This entry represents the transactivation domain of Far upstream element-binding protein 1/2 (FUBP1/2) which is found at the C-terminal. FUBP1 regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. FUBP2, also known as KSRP (K homology-type splicing regulatory protein), is a single-strand-RNA binding protein that integrate different levels of gene expression and is required for proper immune response, lipid metabolism, cell fate decisions, and tissue regeneration [[cite:PUB00084324]]. This domain contains the tyrosine residues required for transactivation and adopts an alpha-helical configuration [[cite:PUB00159898]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00153366":{"PMID":32778776,"ISBN":null,"volume":"10","issue":"1","year":2020,"title":"Comparative structural analyses and nucleotide-binding characterization of the four KH domains of FUBP1.","URL":null,"raw_pages":"13459","medline_journal":"Sci Rep","ISO_journal":"Sci Rep","authors":["Ni X","Knapp S","Chaikuad A."],"DOI_URL":"https://doi.org/10.1038/s41598-020-69832-z"},"PUB00159898":{"PMID":8628294,"ISBN":null,"volume":"16","issue":"5","year":1996,"title":"A unique transactivation sequence motif is found in the carboxyl-terminal domain of the single-strand-binding protein FBP.","URL":null,"raw_pages":"2274-82","medline_journal":"Mol Cell Biol","ISO_journal":"Mol Cell Biol","authors":["Duncan R","Collins I","Tomonaga T","Zhang T","Levens D."],"DOI_URL":"https://doi.org/10.1128/MCB.16.5.2274"},"PUB00084324":{"PMID":24845017,"ISBN":null,"volume":"34","issue":null,"year":2014,"title":"KSRP controls pleiotropic cellular functions.","URL":null,"raw_pages":"2-8","medline_journal":"Semin Cell Dev Biol","ISO_journal":"Semin. Cell Dev. Biol.","authors":["Gherzi R","Chen CY","Ramos A","Briata P."],"DOI_URL":"http://dx.doi.org/10.1016/j.semcdb.2014.05.004"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":66,"interactions":0,"matches":7000,"pathways":0,"proteins":4547,"proteomes":1177,"sets":0,"structural_models":{"alphafold":3925},"structures":2,"taxa":3896},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":15,"alignment:full":5266},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}