{"metadata":{"accession":"PF09004","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR015095","hierarchy":null,"name":{"name":"Alkylated DNA repair protein alkB homolog 8, N-terminal","short":"ALKBH8_N"},"description":[{"text":"<p>This domain is the N-terminal domain of Alkylated DNA repair protein alkB homolog 8 (ALKBH8) and its homologues. This domain corresponds to the basic alpha-helix located at the N-terminal of the RRM domain, which enhances its RNA binding affinity [[cite:PUB00062550]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00062550":{"PMID":22065580,"ISBN":null,"volume":"287","issue":"3","year":2012,"title":"Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification.","URL":null,"raw_pages":"2130-43","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Pastore C","Topalidou I","Forouhar F","Yan AC","Levy M","Hunt JF."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M111.286187"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":794,"interactions":0,"matches":7859,"pathways":0,"proteins":7805,"proteomes":347,"sets":0,"structural_models":{"alphafold":6648},"structures":0,"taxa":1239},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":5108},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}