{"metadata":{"accession":"PF09002","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR015093","hierarchy":null,"name":{"name":"Card1-like, endonuclease domain","short":"Card1_endonuc"},"description":[{"text":"<p>This is the endonuclease domain found in a set of bacterial proteins, including Card1 (cyclic-oligoadenylate-activated single-stranded ribonuclease and single-stranded deoxyribonuclease 1) from Treponema succinifaciens ([swissprot:F2NWD3]), a protein that is part of type III CRISPR-Cas immune response system. This protein consists of a CARF (CRISPR-associated Rossman fold) domain at the N-terminal, an helical hinge domain and a C-terminal endonuclease domain [[cite:PUB00153094]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00153094":{"PMID":33461211,"ISBN":null,"volume":"590","issue":"7847","year":2021,"title":"The Card1 nuclease provides defence during type III CRISPR immunity.","URL":null,"raw_pages":"624-629","medline_journal":"Nature","ISO_journal":"Nature","authors":["Rostol JT","Xie W","Kuryavyi V","Maguin P","Kao K","Froom R","Patel DJ","Marraffini LA."],"DOI_URL":"https://doi.org/10.1038/s41586-021-03206-x"}},"set_info":{"accession":"CL0236","name":"PDDEXK"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":7,"interactions":0,"matches":627,"pathways":0,"proteins":627,"proteomes":597,"sets":1,"structural_models":{"alphafold":429},"structures":8,"taxa":1248},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":314},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}