Members of this family, that are synthesised by Saccharomycetes, adopt a structure consisting of a four-stranded beta-sheet, with strand order beta2-beta1-beta4-beta3, and two alpha-helices, with an overall topology of beta-beta-alpha-beta-beta-alpha. They have no known function [[cite:PUB00029007]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00029007":{"PMID":12717036,"ISBN":null,"volume":"12","issue":"5","year":2003,"title":"A novel member of the split betaalphabeta fold: Solution structure of the hypothetical protein YML108W from Saccharomyces cerevisiae.","URL":null,"raw_pages":"1136-40","medline_journal":"Protein Sci","ISO_journal":"Protein Sci.","authors":["Pineda-Lucena A","Liao JC","Cort JR","Yee A","Kennedy MA","Edwards AM","Arrowsmith CH."],"DOI_URL":"http://dx.doi.org/10.1110/ps.0240903"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":125,"pathways":0,"proteins":125,"proteomes":119,"sets":0,"structural_models":{"alphafold":105},"structures":1,"taxa":242},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":8,"alignment:full":79},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}