{"metadata":{"accession":"PF08983","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR015076","hierarchy":null,"name":{"name":"Vasopressin V1 receptor, C-terminal","short":"V1R_C"},"description":[{"text":"<p>This is the conserved C-terminal domain of Vasopressin V1a/b receptors (V1R), which is involved in receptor trafficking and facilitates the interaction between the intracellular loops of the receptor, the G proteins and coupling to phospholipase C [[cite:PUB00038629],[cite:PUB00098105]]. This domain is unstructured and may reflect its conformational plasticity that may be necessary for proper function of V1R [[cite:PUB00038629]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00098105":{"PMID":23830982,"ISBN":null,"volume":"13","issue":"8","year":2013,"title":"Expression of arginine vasotocin receptors in the developing zebrafish CNS.","URL":null,"raw_pages":"335-42","medline_journal":"Gene Expr Patterns","ISO_journal":"Gene Expr Patterns","authors":["Iwasaki K","Taguchi M","Bonkowsky JL","Kuwada JY."],"DOI_URL":null},"PUB00038629":{"PMID":16511036,"ISBN":null,"volume":"61","issue":"Pt 4","year":2005,"title":"A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein.","URL":null,"raw_pages":"341-5","medline_journal":"Acta Crystallogr Sect F Struct Biol Cryst Commun","ISO_journal":"Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.","authors":["Adikesavan NV","Mahmood SS","Stanley N","Xu Z","Wu N","Thibonnier M","Shoham M."],"DOI_URL":"http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=16511036"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":974,"pathways":0,"proteins":974,"proteomes":595,"sets":0,"structural_models":{"alphafold":857},"structures":5,"taxa":1980},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":8,"alignment:full":742},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1ytv","name":"Maltose-binding protein fusion to a C-terminal fragment of the V1a vasopressin receptor"}}}