Predicted ligand-binding domain of the PPC-like beta-sandwich fold. Observed in conserved gene neighbourhoods with diverse nucleotide-activated effector and related conflict systems, potentially recognises invasive molecules and initiates system responses or directly triggers directly-associated effector domains [[cite:PUB00097693]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00097693":{"PMID":32868406,"ISBN":null,"volume":"202","issue":"24","year":2020,"title":"Identification of Uncharacterized Components of Prokaryotic Immune Systems and Their Diverse Eukaryotic Reformulations.","URL":null,"raw_pages":null,"medline_journal":"J Bacteriol","ISO_journal":"J Bacteriol","authors":["Burroughs AM","Aravind L."],"DOI_URL":null}},"set_info":{"accession":"CL0202","name":"GBD"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":930,"pathways":0,"proteins":930,"proteomes":889,"sets":1,"structural_models":{"alphafold":547},"structures":1,"taxa":1349},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":4,"alignment:full":262},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2b1y","name":"Crystal Structure of Protein of Unknown Function ATU1913 from Agrobacterium tumefaciens str. C58"}}}