Members of this family have an important role in methanogenesis. They assume an alpha-beta globular structure consisting of six beta-strands and three alpha-helices forming the secondary structural topological arrangement of alpha1-beta1-alpha2-beta2-beta3-beta4-beta5-beta6-alpha3 [[cite:PUB00035386]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00035386":{"PMID":16222557,"ISBN":null,"volume":"33","issue":"1","year":2005,"title":"Solution Structure of MTH0776 from Methanobacterium thermoautotrophicum.","URL":null,"raw_pages":"51-6","medline_journal":"J Biomol NMR","ISO_journal":"J. Biomol. NMR","authors":["Amegbey G","Stothard P","Kuznetsova E","Yee A","Arrowsmith CH","Wishart DS."],"DOI_URL":"http://dx.doi.org/10.1007/s10858-005-1275-5"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":199,"pathways":0,"proteins":198,"proteomes":145,"sets":0,"structural_models":{"alphafold":171},"structures":1,"taxa":264},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":66,"alignment:full":74},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}