Members of this family of prokaryotic proteins adopt a fold consisting of one alpha-helix and four beta-strands. Their function has not, as yet, been elucidated [[cite:PUB00035388]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00035388":{"PMID":16250002,"ISBN":null,"volume":"61","issue":"4","year":2005,"title":"Crystal structure of the hypothetical protein TTHA1013 from Thermus thermophilus HB8.","URL":null,"raw_pages":"1117-20","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Hattori M","Mizohata E","Manzoku M","Bessho Y","Murayama K","Terada T","Kuramitsu S","Shirouzu M","Yokoyama S."],"DOI_URL":"http://dx.doi.org/10.1002/prot.20692"}},"set_info":{"accession":"CL0057","name":"Met_repress"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":439,"pathways":0,"proteins":439,"proteomes":402,"sets":1,"structural_models":{"alphafold":287},"structures":1,"taxa":946},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":278},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}