{"metadata":{"accession":"PF08965","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR015060","hierarchy":null,"name":{"name":"Aca2/YdiL-like","short":"Aca2_YdiL"},"description":[{"text":"<p>This domain is found in Aca2 repressor from Pectobacterium phage ZF40, the uncharacterised protein YdiL from Escherichia coli and related sequences. Aca2 regulates the transcription and translation of phage anti-CRISPR acrIF8 gene through DNA binding and translationally by binding conserved RNA stem-loops on mRNAs. This protein contains six alpha-helices and two parallel beta-strands [[cite:PUB00160094],[cite:PUB00158951],[cite:PUB00158952]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00158951":{"PMID":34756887,"ISBN":null,"volume":"297","issue":"6","year":2021,"title":"Structural basis for anti-CRISPR repression mediated by bacterial operon proteins Aca1 and Aca2.","URL":null,"raw_pages":"101357","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Liu Y","Zhang L","Guo M","Chen L","Wu B","Huang H."],"DOI_URL":"https://doi.org/10.1016/j.jbc.2021.101357"},"PUB00160094":{"PMID":34116143,"ISBN":null,"volume":"213","issue":"3","year":2021,"title":"Crystal structure of the anti-CRISPR repressor Aca2.","URL":null,"raw_pages":"107752","medline_journal":"J Struct Biol","ISO_journal":"J Struct Biol","authors":["Usher B","Birkholz N","Beck IN","Fagerlund RD","Jackson SA","Fineran PC","Blower TR."],"DOI_URL":"https://doi.org/10.1016/j.jsb.2021.107752"},"PUB00158950":{"PMID":31428783,"ISBN":null,"volume":"47","issue":"18","year":2019,"title":"The autoregulator Aca2 mediates anti-CRISPR repression.","URL":null,"raw_pages":"9658-9665","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res","authors":["Birkholz N","Fagerlund RD","Smith LM","Jackson SA","Fineran PC."],"DOI_URL":"https://doi.org/10.1093/nar/gkz721"},"PUB00158952":{"PMID":38987591,"ISBN":null,"volume":"631","issue":"8021","year":2024,"title":"Phage anti-CRISPR control by an RNA- and DNA-binding helix-turn-helix protein.","URL":null,"raw_pages":"670-677","medline_journal":"Nature","ISO_journal":"Nature","authors":["Birkholz N","Kamata K","Feussner M","Wilkinson ME","Cuba Samaniego C","Migur A","Kimanius D","Ceelen M","Went SC","Usher B","Blower TR","Brown CM","Beisel CL","Weinberg Z","Fagerlund RD","Jackson SA","Fineran PC."],"DOI_URL":"https://doi.org/10.1038/s41586-024-07644-1"}},"set_info":{"accession":"CL0123","name":"HTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":173,"pathways":0,"proteins":173,"proteomes":166,"sets":1,"structural_models":{"alphafold":104},"structures":7,"taxa":364},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":4,"alignment:full":61},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1s4k","name":"Putative cytoplasmic protein from Salmonella typhimurium"}}}