{"metadata":{"accession":"PF08961","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR015056","hierarchy":null,"name":{"name":"Nuclear receptor-binding factor 2, autophagy regulator","short":"NRBF2"},"description":[{"text":"<p>NRBF2 plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes.  NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3 kinase) activity and autophagy induction [[cite:PUB00078728]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00078727":{"PMID":10786636,"ISBN":null,"volume":"1490","issue":"1-2","year":2000,"title":"Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors.","URL":null,"raw_pages":"189-97","medline_journal":"Biochim Biophys Acta","ISO_journal":"Biochim. Biophys. Acta","authors":["Yasumo H","Masuda N","Furusawa T","Tsukamoto T","Sadano H","Osumi T."],"DOI_URL":"http://dx.doi.org/10.1016/S0167-4781(99)00244-4"},"PUB00078728":{"PMID":24849286,"ISBN":null,"volume":"5","issue":null,"year":2014,"title":"NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity.","URL":null,"raw_pages":"3920","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Lu J","He L","Behrends C","Araki M","Araki K","Jun Wang Q","Catanzaro JM","Friedman SL","Zong WX","Fiel MI","Li M","Yue Z."],"DOI_URL":"http://dx.doi.org/10.1038/ncomms4920"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":1024,"pathways":0,"proteins":1024,"proteomes":729,"sets":0,"structural_models":{"alphafold":919},"structures":1,"taxa":2224},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":875},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}