{"metadata":{"accession":"PF08939","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR015034","hierarchy":null,"name":{"name":"Basophilic leukemia-expressed protein Bles03","short":"Bles03"},"description":[{"text":"<p>This domain is found in Basophilic leukemia-expressed protein Bles03 from humans (also known as UPF0696 protein C11orf68, [swissprot:Q9H3H3]) and various proteins from eukaryotes, bacteria and archaea. Bles03 has been suggested to have phosphothreonine lyase activity and to play a role in the biosynthesis of dehydro amino acids [[cite:PUB00039014]]. It shows a two-layer sandwich architecture with a a nine-stranded beta-sheet and three alpha-helices on each side [[cite:PUB00100679]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00039014":{"PMID":16511166,"ISBN":null,"volume":"61","issue":"Pt 9","year":2005,"title":"The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03.","URL":null,"raw_pages":"812-7","medline_journal":"Acta Crystallogr Sect F Struct Biol Cryst Commun","ISO_journal":"Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.","authors":["Bitto E","Bingman CA","Robinson H","Allard ST","Wesenberg GE","Phillips GN Jr."],"DOI_URL":"http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=16511166"},"PUB00100679":{"PMID":25062915,"ISBN":null,"volume":"6","issue":"8","year":2014,"title":"Genome-wide search for eliminylating domains reveals novel function for BLES03-like proteins.","URL":null,"raw_pages":"2017-33","medline_journal":"Genome Biol Evol","ISO_journal":"Genome Biol Evol","authors":["Khater S","Mohanty D."],"DOI_URL":null}},"set_info":{"accession":"CL0625","name":"eIF4e"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":40,"interactions":0,"matches":1995,"pathways":0,"proteins":1951,"proteomes":1597,"sets":1,"structural_models":{"alphafold":1644},"structures":2,"taxa":4096},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":23,"alignment:full":1531},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}