{"metadata":{"accession":"PF08937","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR015032","hierarchy":null,"name":{"name":"Thoeris protein ThsB, TIR-like domain","short":"ThsB_TIR"},"description":[{"text":"<p>Thoeris is a bacterial antiphage defense system, which consists of two genes, thsA and thsB, via NAD+ degradation [[cite:PUB00097806],[cite:PUB00101118],[cite:PUB00101117]]. ThsA has robust NAD+ cleavage activity and and a two-domain architecture containing a N-terminal NAD-binding domain (denoted as sirtuin-like or Macro) and C-terminal SLOG-like domain. In some instances, such as in B. amyloliquefaciens ThsA has an N-terminal transmembrane domain [[cite:PUB00097806]]. ThsB (also referred to as TIR1 and TIR2) is structurally similar to TIR domain proteins but without enzymatic activity. This is the TIR-like domain of ThsB proteins,  which adopts a Rossmann-like fold. ThsB is responsible for recognizing phage infection [[cite:PUB00101118]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00101117":{"PMID":32499527,"ISBN":null,"volume":"11","issue":"1","year":2020,"title":"Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD<sup>+</sup> degradation.","URL":null,"raw_pages":"2816","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Ka D","Oh H","Park E","Kim JH","Bae E."],"DOI_URL":null},"PUB00101118":{"PMID":34853457,"ISBN":null,"volume":"600","issue":"7887","year":2021,"title":"Antiviral activity of bacterial TIR domains via immune signalling molecules.","URL":null,"raw_pages":"116-120","medline_journal":"Nature","ISO_journal":"Nature","authors":["Ofir G","Herbst E","Baroz M","Cohen D","Millman A","Doron S","Tal N","Malheiro DBA","Malitsky S","Amitai G","Sorek R."],"DOI_URL":null},"PUB00097806":{"PMID":29371424,"ISBN":null,"volume":"359","issue":"6379","year":2018,"title":"Systematic discovery of antiphage defense systems in the microbial pangenome.","URL":null,"raw_pages":null,"medline_journal":"Science","ISO_journal":"Science","authors":["Doron S","Melamed S","Ofir G","Leavitt A","Lopatina A","Keren M","Amitai G","Sorek R."],"DOI_URL":null}},"set_info":{"accession":"CL0173","name":"STIR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":23,"interactions":0,"matches":2293,"pathways":0,"proteins":2293,"proteomes":1821,"sets":1,"structural_models":{"alphafold":1413},"structures":8,"taxa":3640},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":28,"alignment:full":1073},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"8fz9","name":"Crystal Structure of Bacillus cereus TIR protein"}}}