This domain is predominantly found in viral proteins from the family Picornaviridae. It is VP4 of the viral polyprotein which, in poliovirus, is part of the capsid that consists of 60 copies each of four proteins VP1, VP2, VP3, and VP4 arranged on an icosahedral lattice [[cite:PUB00109098]]. VP4 is on the inside and differs from the others in being small, myristoylated and having an extended structure. Productive infection involves the externalisation of the VP4, which is cleaved from the rest, along with the N-terminus of VP1. There thus seem to be three stages of the virus, ie a multi-step process for cell entry involving RNA translocation through a membrane channel formed by the externalised N termini of VP1 [[cite:PUB00109099]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00109099":{"PMID":10627545,"ISBN":null,"volume":"74","issue":"3","year":2000,"title":"Molecular tectonic model of virus structural transitions: the putative cell entry states of poliovirus.","URL":null,"raw_pages":"1342-54","medline_journal":"J Virol","ISO_journal":"J Virol","authors":["Belnap DM","Filman DJ","Trus BL","Cheng N","Booy FP","Conway JF","Curry S","Hiremath CN","Tsang SK","Steven AC","Hogle JM."],"DOI_URL":null},"PUB00109098":{"PMID":9371640,"ISBN":null,"volume":"71","issue":"12","year":1997,"title":"Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus.","URL":null,"raw_pages":"9743-52","medline_journal":"J Virol","ISO_journal":"J Virol","authors":["Curry S","Fry E","Blakemore W","Abu-Ghazaleh R","Jackson T","King A","Lea S","Newman J","Stuart D."],"DOI_URL":null}},"set_info":{"accession":"CL0055","name":"Nucleoplasmin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":93,"pathways":0,"proteins":93,"proteomes":36,"sets":1,"structural_models":{"alphafold":35},"structures":10,"taxa":86},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":1,"alignment:full":3},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}