The structure of this domain displays an alpha-beta-beta-alpha four layer topology, with an HxHxxxxxxxxxH motif that coordinates a zinc ion, and an acetate anion at a site that likely supports the enzymatic activity of an ester hydrolase [[cite:PUB00035389]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00035389":{"PMID":16522806,"ISBN":null,"volume":"15","issue":"4","year":2006,"title":"Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase fold.","URL":null,"raw_pages":"914-20","medline_journal":"Protein Sci","ISO_journal":"Protein Sci.","authors":["Manjasetty BA","Bussow K","Fieber-Erdmann M","Roske Y","Gobom J","Scheich C","Gotz F","Niesen FH","Heinemann U."],"DOI_URL":"http://dx.doi.org/10.1110/ps.052037006"}},"set_info":{"accession":"CL0615","name":"ALDC"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":46,"interactions":0,"matches":2361,"pathways":0,"proteins":2209,"proteomes":1513,"sets":1,"structural_models":{"alphafold":1929},"structures":1,"taxa":4543},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":45,"alignment:full":1894},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1xcr","name":"Crystal Structure of Longer Splice Variant of PTD012 from Homo sapiens reveals a novel Zinc-containing fold"}}}