{"metadata":{"accession":"PF08924","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR015020","hierarchy":null,"name":{"name":"Rv2525c-like, glycoside hydrolase-like domain","short":"Rv2525c_GlyHyd-like"},"description":[{"text":"<p>This domain is found in uncharacterised bacterial proteins, including the putative peptidoglycan hydrolase Rv2525c from Mycobacterium tuberculosis [[cite:PUB00100887],[cite:PUB00100886]]. It has been proposed to function as a peptidoglycan hydrolase with glycosidase activity regarding structural studies showed that this domain has a typical TIM-barrel-like fold, characteristic of glycoside hydrolases [[cite:PUB00100887]]. However, it displays esterase activity toward p-nitrophenyl esters of various acyl chain length in vitro [[cite:PUB00100886]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100886":{"PMID":25869294,"ISBN":null,"volume":"176","issue":"1","year":2015,"title":"Expression, Purification and Characterisation of Secreted Esterase Rv2525c from Mycobacterium tuberculosis.","URL":null,"raw_pages":"1-12","medline_journal":"Appl Biochem Biotechnol","ISO_journal":"Appl Biochem Biotechnol","authors":["Dang G","Chen L","Li Z","Deng X","Cui Y","Cao J","Yu S","Pang H","Liu S."],"DOI_URL":null},"PUB00100887":{"PMID":25260828,"ISBN":null,"volume":"188","issue":"2","year":2014,"title":"Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.","URL":null,"raw_pages":"156-64","medline_journal":"J Struct Biol","ISO_journal":"J Struct Biol","authors":["Bellinzoni M","Haouz A","Miras I","Magnet S","Andre-Leroux G","Mukherjee R","Shepard W","Cole ST","Alzari PM."],"DOI_URL":null}},"set_info":{"accession":"CL0036","name":"TIM_barrel"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":98,"interactions":0,"matches":3876,"pathways":0,"proteins":3876,"proteomes":2610,"sets":1,"structural_models":{"alphafold":2197},"structures":5,"taxa":3609},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":72,"alignment:full":1812},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4pmq","name":"Crystal structure of the Mycobacterium tuberculosis Tat-secreted protein Rv2525c in complex with L-tartrate (orthorhombic crystal form)"}}}